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外周苯二氮受體抗體
  • 產品貨號：
    BN41873R
  • 中文名稱：
    外周苯二氮受體抗體
  • 英文名稱：
    Rabbit anti-TSPO/PBR Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產品規(guī)格

    售價

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  • BN41873R-50ul

    50ul

    ￥1486.00

    交叉反應：Human,Mouse,Rat(predicted:Dog,Pig) 推薦應用：IHC-P,IHC-F,IF,Flow-Cyt,ELISA

  • BN41873R-100ul

    100ul

    ￥2360.00

    交叉反應：Human,Mouse,Rat(predicted:Dog,Pig) 推薦應用：IHC-P,IHC-F,IF,Flow-Cyt,ELISA

  • BN41873R-200ul

    200ul

    ￥3490.00

    交叉反應：Human,Mouse,Rat(predicted:Dog,Pig) 推薦應用：IHC-P,IHC-F,IF,Flow-Cyt,ELISA

產品描述

英文名稱TSPO/PBR
中文名稱外周苯二氮受體抗體
別    名BPBS; BZRP; DBI; IBP; Isoquinoline carboxamide-binding protein; MBR; mDRC; Mitochondrial benzodiazepine receptor; PBR; PBS; Peripheral benzodiazepine receptor; Peripheral benzodiazepine receptor-related protein; Peripheral type benzodiazepine receptor; pk18; PKBS; PTBR; Ptbzr; PTBZR02; RATPTBZR02; translocator protein (18kDa); Translocator protein; TSPO; Tspo1; Benzodiazapine receptor (peripheral); Benzodiazepine peripheral binding site.  
研究領域細胞生物  免疫學  神經生物學  轉錄調節(jié)因子  糖尿病  線粒體  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應Mouse, Rat,  (predicted: Human, Dog, Pig, )
產品應用ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量18kDa
細胞定位細胞漿 線粒體
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human PBR:31-130/169 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產品介紹PBR (Peripheral type Benzodiazepine Receptor) is a ubiquitous protein (18 kDa) found in most steroidogenic tissues. It is located primarily in the outer mitochondrial membrane of steroid producing tissues and is found in association with a 34 kDa voltage dependent anion channel protein (VDAC). PBR interacts with some benzodiazepines and has different affinities than its endogenous counterpart. PBR appears to be a key factor in the transport of cholesterol from the outer to the inner mitochondrial membrane to permit the initiation of steroid hormone synthesis. It is thought to be part of the mitochondrial permeability transition pore (PT) and to be involved in apoptosis. It is speculated that patients with congenital lipoid adrenal hyperplasia, who cannot make any steroids, might have a genetic lesion in BZRP. A short form, PBRS is also expressed in the same tissues, but at a level about ten times that of PBR.

Function:
Responsible for the manifestation of peripheral-type benzodiazepine recognition sites and is most likely to comprise binding domains for benzodiazepines and isoquinoline carboxamides. May play a role in the transport of porphyrins and heme. Plays a role in the transport of cholesterol across mitochondrial membranes in steroidogenic cells.

Subcellular Location:
Mitochondrion membrane.

Tissue Specificity:
Found in many tissue types. Expressed at the highest levels under normal conditions in tissues that synthesize steroids.

Similarity:
Belongs to the TspO/BZRP family.

SWISS:
B1AH88

Gene ID:
706

Database links:

Entrez Gene: 706 Human

Entrez Gene: 12257 Mouse

Omim: 109610 Human

SwissProt: B1AH88 Human

SwissProt: P30536 Human

SwissProt: P50637 Mouse

Unigene: 202 Human

Unigene: 1508 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

地西泮結合抑制因子； DBI能拮抗安定物質：diazepam與腦突觸膜相結合 ,故稱之為安定結合抑制蛋白(DBI)，地西泮結合抑制因子(diazepam binding inhibitor,DBI)具有抑制由葡萄糖誘導的胰島素分泌、促進膽固醇跨線粒體膜轉運和調節(jié)脂肪酸合成與代謝等多種生理功能。




















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