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磷酸化蛋白質酪氨酸激酶JAK-1抗體
  • 產品貨號：
    BN40887R
  • 中文名稱：
    磷酸化蛋白質酪氨酸激酶JAK-1抗體
  • 英文名稱：
    Rabbit anti-Phospho-Jak1 (Tyr1034 + Tyr1035) Polyclonal antibody
  • 品牌：
    Biorigin

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  • BN40887R-100ul

    100ul

    ￥2470.00

    交叉反應：Human(predicted:Mouse,Rat,Pig,Cow) 推薦應用：WB,Flow-Cyt,ELISA

產品描述

英文名稱Phospho-Jak1 (Tyr1034 + Tyr1035)
中文名稱磷酸化蛋白質酪氨酸激酶JAK-1抗體
別    名JAK1 (phospho Y1034 + Y1035); p-JAK1 (phospho Y1034 + Y1035); JAK 1; JAK 1A; JAK 1B; JAK-1; JAK1; JAK1_HUMAN; JAK1A; JAK1B; Janus kinase 1 (a protein tyrosine kinase); Janus kinase 1; JTK3; Tyrosine protein kinase JAK 1; Tyrosine protein kinase JAK1; Tyrosine-protein kinase JAK1.  


產品類型磷酸化抗體 
研究領域腫瘤  細胞生物  免疫學  染色質和核信號  信號轉導  細胞凋亡  激酶和磷酸酶  表觀遺傳學  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應Human,  (predicted: Mouse, Rat, Pig, Cow, )
產品應用WB=1:500-2000 ELISA=1:5000-10000 Flow-Cyt=2μg /Test 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量133kDa
細胞定位細胞膜 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated Synthesised phosphopeptide derived from human Jak1 around the phosphorylation site of Tyr1034 + Tyr1035:KE(p-Y)(p-Y)TV 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產品介紹Janus kinase 1 (JAK1) is a member of a new class of non-receptor protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The second phosphotransferase domain bears all the hallmarks of a protein kinase, although its structure differs significantly from that of the PTK and threonine/serine kinase family members. JAK1 is a large, widely expressed membrane-associated phosphoprotein. It is involved in the interferon-alpha/beta and -gamma signal transduction pathways. The reciprocal interdependence between JAK1 and TYK2 activities in the interferon-alpha pathway, and between JAK1 and JAK2 in the interferon-gamma pathway, may reflect a requirement for these kinases in the correct assembly of interferon recpeptor complexes. These kinases couple cytokine ligand binding to tyrosine phosphorylation of various known signaling proteins and a unique family of transcription factors termed the signal transducers and activators of transcription, or STATs.

Function:
Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor.

Subunit:
Interacts with FER. Interacts with IL31RA, IFNAR2, JAKMIP1 and SHB.

Subcellular Location:
Endomembrane system; Peripheral membrane protein. Note=Wholly intracellular, possibly membrane associated.

Tissue Specificity:
Expressed at higher levels in primary colon tumors than in normal colon tissue. The expression level in metastatic colon tumors is comparable to the expression level in normal colon tissue.

Similarity:
Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.
Contains 1 FERM domain.
Contains 1 protein kinase domain.
Contains 1 SH2 domain.

SWISS:
P23458

Gene ID:
3716

Database links:

Entrez Gene: 3716 Human

Entrez Gene: 442952 Dog

Entrez Gene: 16451 Mouse

Entrez Gene: 84598 Rat

Omim: 147795 Human

SwissProt: P23458 Human

SwissProt: P52332 Mouse

Unigene: 207538 Human

Unigene: 289657 Mouse

Unigene: 90191 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

















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