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轉(zhuǎn)錄因子Tbx3抗體
  • 產(chǎn)品貨號：
    BN40710R
  • 中文名稱：
    轉(zhuǎn)錄因子Tbx3抗體
  • 英文名稱：
    Rabbit anti-TBX3 Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

    售價

    備注

  • BN40710R-100ul

    100ul

    ￥2360.00

    交叉反應：Mouse,Rat(predicted:Human,Rabbit) 推薦應用：IHC-P

  • BN40710R-200ul

    200ul

    ￥3490.00

    交叉反應：Mouse,Rat(predicted:Human,Rabbit) 推薦應用：IHC-P

產(chǎn)品描述

英文名稱TBX3
中文名稱轉(zhuǎn)錄因子Tbx3抗體
別    名T-box protein 3; T-box transcription factor TBX3; TBX3; TBX3-ISO; TBX3 ISO; UMS; XHL; Bladder cancer related protein XHL; T box 3; TBX3_HUMAN.  
研究領域細胞生物  神經(jīng)生物學  細胞凋亡  轉(zhuǎn)錄調(diào)節(jié)因子  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應Mouse, Rat,  (predicted: Human, Rabbit, )
產(chǎn)品應用IHC-P=1:100-500 （石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量82kDa
細胞定位細胞核 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human TBX3:181-280/743 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹Tbx3 gene is a member of a phylogenetically conserved family of genes that share a common DNA binding domain, the T box. T box genes encode transcription factors involved in the regulation of developmental processes. Tbx3 is a transcriptional repressor and is thought to play a role in the anterior/posterior axis of the tetrapod forelimb. Mutations in this gene cause ulnar mammary syndrome, affecting limb, apocrine gland, tooth, hair, and genital development. Alternative splicing of this gene results in three transcript variants encoding different isoforms; however, the full length nature of one variant has not been determined.

Function:
Transcriptional repressor involved in developmental processes. Probably plays a role in limb pattern formation.

Subcellular Location:
Nucleus (Potential).

Tissue Specificity:
Widely expressed.

DISEASE:
Defects in TBX3 are the cause of ulnar-mammary syndrome (UMS) [MIM:181450]. UMS is characterized by ulnar ray defects, obesity, hypogenitalism, delayed puberty, hypoplasia of nipples and apocrine glands.

Similarity:
Contains 1 T-box DNA-binding domain.

SWISS:
O15119

Gene ID:
6926

Database links:
Entrez Gene: 6926 Human

Entrez Gene: 21386 Mouse

Entrez Gene: 353305 Rat

Omim: 601621 Human

SwissProt: O15119 Human

SwissProt: P70324 Mouse

SwissProt: Q7TST9 Rat

Unigene: 129895 Human

Unigene: 219139 Mouse

Unigene: 162144 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.














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